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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Hepatology. 2023 Apr 1;78(2):503–517. doi: 10.1097/HEP.0000000000000373

Figure 1. Decreased hepatic TSC1 protein and increased mTORC1 activation in human AH and Gao-binge alcohol fed mouse livers.

Figure 1.

Representative photographs of IHC staining of TSC1 (A), H&E staining (B) & IHC staining of CK19 (C) on liver tissues from AH and healthy donors (control) are shown. Right panel is an enlarged photograph from the boxed area. Arrows denote DR or CK19 positive DR. (D) Total liver lysates from AH or healthy donors (control) were subjected to western blot analysis. (E) Male 8-weeks old WT mice were subjected to Gao-binge alcohol (EtOH) feeding and total liver lysates were subjected to western blot analysis. Liver lysates from a control diet fed L-Tsc1 KO mice were used as a positive control.