Table 2.
Propensity score-matched cohort characteristics by treatment group for PFT vs RFT
| Characteristic | PFT N=1,868 |
RFT N=1,868 |
p-value |
|---|---|---|---|
| Age, mean (SD) | 61.6 (7.9) | 61.7 (8.2) | 0.57 |
| Men, N (%) | 1,853 (99.2) | 1,854 (99.3) | 0.72 |
| Race/Ethnicity, N (%) | 0.92 | ||
| Caucasian | 1,512 (80.9) | 1,516 (81.2) | |
| African American | 282 (15.1) | 272 (14.6) | |
| Hispanic | 47 (2.5) | 49 (2.6) | |
| Other* | 27 (1.5) | 31 (1.7) | |
| Year of diagnosis, N (%) | 0.45 | ||
| 2000-2005 | 429 (23.0) | 462 (24.7) | |
| 2006-2010 | 699 (37.4) | 686 (36.7) | |
| 2011-2014 | 740 (39.6) | 720 (38.5) | |
| Radiation Dose, cGy, mean (SD) | 6,352 (4,202) | 6,647 (6,223) | 0.11 |
| Chemotherapy Regiment, N (%) | 0.002 | ||
| Single-agent | 1,170 (62.6) | 1,066 (57.1) | |
| Multiagent | 610 (32.7) | 713 (38.1) | |
| NOS | 88 (4.7) | 89 (4.8) | |
| Smoking Status, N (%) | 0.95 | ||
| Current cigarette | 1,120 (60.0) | 1,100 (58.9) | |
| Current cigar/pipe/smokeless | 45 (2.4) | 44 (2.4) | |
| Former | 529 (28.3) | 552 (29.6) | |
| Never | 151 (8.1) | 148 (7.9) | |
| Missing | 23 (1.2) | 24 (1.3) | |
| Alcohol Use, N (%) | |||
| Yes | 1,474 (78.9) | 1,431 (76.6) | 0.16 |
| Missing | 110 (5.9) | 124 (6.6) | |
| Anatomic Site, N (%) | 0.73 | ||
| Oral Cavity | 150 (8.0) | 142 (7.6) | |
| Oropharynx | 1,143 (61.2) | 1,131 (60.6) | |
| Hypopharynx/Larynx | 575 (30.8) | 595 (31.9) | |
| Stage at Diagnosis, N (%) | 0.68 | ||
| III | 391 (20.9) | 421 (22.5) | |
| IVA | 1,238 (66.3) | 1,213 (64.9) | |
| IVB | 183 (9.8) | 182 (9.7) | |
| IVC | 56 (3.0) | 52 (2.8) | |
| Clinical T, N (%) | 0.53 | ||
| 1 | 223 (11.9) | 229 (12.3) | |
| 2 | 578 (30.9) | 576 (30.8) | |
| 3 | 534 (28.6) | 550 (29.4) | |
| 4 | 495 (26.5) | 471 (25.2) | |
| Missing | 38 (2.0) | 42 (2.3) | |
| Clinical N, N (%) | 0.90 | ||
| 0 | 258 (13.8) | 271 (14.5) | |
| 1 | 291 (15.6) | 301 (16.1) | |
| 2 | 1,161 (62.2) | 1,131 (60.5) | |
| 3 | 126 (6.7) | 130 (7.0) | |
| Missing | 32 (1.7) | 35 (1.9) | |
| eGFR, mg/dl, median (IQR) | 85 (69-100) | 84 (69-99) | 0.11 |
| Baseline Hearing Loss, N (%) | 251 (13.4) | 257 (13.8) | 0.78 |
| Baseline Neuropathy | 138 (7.4) | 135 (7.2) | 0.85 |
| Comorbidity Score, N (%) | 0.96 | ||
| 0 | 771 (41.3) | 774 (41.4) | |
| 1 | 454 (24.3) | 447 (23.9) | |
| >1 | 643 (34.4) | 647 (34.6) |
Abbreviations: PFT, prophylactic feeding tube; cGy, centigray; eGFR, estimated glomerular filtration rate; ΔBMI, change in BMI