Table 2.
Baseline characteristics of the study population
| Variables | Baseline characteristics of UC | P | Baseline characteristics of CD | P | ||
|---|---|---|---|---|---|---|
| Responders | Non-responders | Responders | Non-responders | |||
| (n = 41) | (n = 28) | (n = 47) | (n = 25) | |||
| Age (years) | 50.00(32.50–55.50) | 45.50(35.25–55.50) | 0.956 | 25.00(22.00–41.00) | 29.00(20.00–39.00) | 0.696 |
| Male, n (%) | 20(48.78%) | 18(64.29%) | 0.228 | 29(61.70%) | 18(72.00%) | 0.444 |
| BMI (kg/m2) | 20.58(18.99–24.57) | 19.35(17.41–21.54) | 0.024 | 18.78 ± 2.83 | 18.09 ± 4.37 | 0.477 |
| Temperature > 37.8 °C, n (%) | 9(21.95%) | 10(35.71%) | 0.275 | 16(34.04%) | 10(40.00%) | 0.618 |
| ESR (mm/h) | 43.98 ± 30.00 | 58.14 ± 30.52 | 0.060 | 48.41 ± 30.62 | 55.05 ± 30.93 | 0.385 |
| CRP (mg/L) | 55.00(15.74–85.78) | 55.86(14.65–90.91) | 0.687 | 36.50(13.60–68.60) | 48.60(19.58–74.46) | 0.391 |
| Hb (g/L) | 102.98 ± 23.87 | 115.18 ± 26.62 | 0.051 | 105.98 ± 25.94 | 101.84 ± 26.67 | 0.525 |
| Alb (g/L) | 33.35 ± 6.49 | 33.40 ± 6.76 | 0.975 | 35.84 ± 6.64 | 30.66 ± 7.37 | 0.003 |
| CMV seropositivity, n (%) | 5(12.20%) | 5(17.86) | 0.729 | 0(0.00%) | 0(0.00%) | - |
| Disease duration (months) | 18.00(8.50–66.00) | 12.00(1.25–24.00) | 0.069 | 12.00(5.00–36.00) | 16.00(6.50–48.00) | 0.275 |
| Disease extent, n (%) | 0.321 | - | ||||
| Proctitis (E1) | 4(9.76%) | 1(3.57%) | ||||
| Left-sided colitis (E2) | 14(34.14%) | 6(21.43%) | ||||
| Extensive colitis (E3) | 23(56.10%) | 21(75.00%) | ||||
| Disease location, n (%) | - | 0.544 | ||||
| Ileal (L1) | 9(19.15%) | 3(12.00%) | ||||
| Colonic (L2) | 13(27.66%) | 5(20.00%) | ||||
| Ileocolonic (L3) | 25(53.19%) | 17(68.00%) | ||||
| Disease behavior, n (%) | 0.239 | |||||
| Inflammatory (B1) | 38(80.85%) | 16(64.00%) | ||||
| Stricturing (B2) | 6(12.77%) | 7(28.00%) | ||||
| Penetrating (B3) | 3(6.38%) | 2(8.00%) | ||||
| Stool frequency (n/day) | 7(6–12) | 9(6–12) | 0.319 | 5(3–7) | 4(2–8) | 0.392 |
| Bloody stools, n (%) | 41(100.00%) | 28(100.00%) | - | 20(42.55%) | 8(32.00%) | 0.452 |
| Parenteral manifestations, n (%) | 5(12.20%) | 7(25.00%) | 0.205 | 20(42.55%) | 10(40.00%) | > 0.999 |
| Clinical severity (SCCAI/HBI) | 10(9–11) | 11(10–12) | 0.012 | 14(13–17) | 16(16–18) | 0.049 |
| Endoscopic severity (UECIS/SES-CD) | 6(6–7) | 6(5–7) | 0.290 | 16(14–20) | 17(16–22) | 0.184 |
| Colonic dilatation, n (%) | 4(9.76%) | 7(25.00%) | 0.106 | 2(4.26%) | 2(8.00%) | 0.606 |
| SATI (cm2/m2) | 42.29 ± 20.41 | 21.16 ± 9.64 | < 0.001 | 16.21(9.92–32.65) | 21.23(5.77–34.65) | 0.882 |
| VATI (cm2/m2) | 24.43(13.46–41.53) | 14.71(8.56–18.41) | 0.001 | 11.63(6.50–17.89) | 21.33(11.32–33.02) | 0.004 |
| PSAI (cm2/m2) | 1.37(0.84–1.61) | 1.15(0.98–1.34) | 0.124 | 0.82(0.53–0.96) | 0.79(0.65–1.05) | 0.590 |
| MATI (cm2/m2) | 5.33 ± 1.79 | 4.20 ± 2.32 | 0.025 | 3.44(2.40–4.95) | 3.14(1.69–6.27) | 0.892 |
| MFI (cm2/m2) | 0.62(0.52–0.82) | 0.73(0.61–0.82) | 0.136 | 0.61(0.43–0.86) | 1.11(0.88–1.49) | < 0.001 |
Normally distributed continuous variables are described as means ± SDs, while non-normally distributed continuous variables are presented as medians with 25% and 75% quartiles. Categorized variables are given as absolute numbers and percentages
UC Ulcerative colitis, CD Crohn’s disease, BMI Body mass index, ESR Erythrocyte sedimentation rate, CRP C-reactive protein, Hb Hemoglobin, Alb Albumin, CMV Cytomegalovirus, SCCAI Simple Clinical Colitis Activity Index, HBI Harvey-Bradshaw Index, UCEIS Ulcerative Colitis Endoscopic Index of Severity, SES-CD Simple Endoscopic Score for Crohn’s Disease, SATI Subcutaneous adipose tissue index, VATI Visceral adipose tissue index, PSAI Paraspinal intramuscular adipose tissue index, MATI Mesorectal adipose tissue index, MFI Mesenteric fat index, SDs Standard deviations