Table 2.

Medication subclasses commonly prescribed and potentially associated with FRIs in older adults

Medication class	Subclass of the study medications	ATC-codes	Reference
Cardiovascular	ACE inhibitors	C09A-C09B, C10BX13, C10BX04, C10BX06, C10BX07, C10BX11, C10BX12, C10BX14	[11, 12, 15, 29, 35, 43]
	Angiotensin II antagonists	C09C-C09D, C10BX10	[12, 15, 29, 35, 43]
	Beta-blocking agents	C07, C09BX02	[11, 12, 15, 29, 35, 43]
	Calcium channel blockers	C08, C07FB, C09BB, C09DB, C09BX01, C09BX3, C09DX01, C09DX03, C10BX03, C10BX07, C10BX09, C10BX11, C10BX14	[12, 15, 35, 43]
	Cardiac glycosides	C01A	[11, 29, 44]
	Vasodilators	C02D, C04, C07E	[11, 12]
	Diuretics	C03, C07B- C07D, C08G, C09BA, C09DA, C09BX01, C09BX03, C09DX01, C09DX03, C10BX13	[11, 12, 15, 17, 29, 35, 45]
	Antithrombotic agents	B01, C07FX02-C07FX04, C10BX01, C10BX02, C10BX04- C10BX06, C10BX08, C10BX12	[14, 46]
	Lipid-modifying agents	C10, A10BH51	[12, 44, 46]
Nervous system	Antipsychotics	N05A	[10, 11, 13, 17, 45, 47]
	Antidepressants	N06A	[10, 11, 13, 17, 47]
	Anxiolytics	N05B	[13, 45, 47]
	Hypnotics and sedatives	N05C	[13, 17, 44, 45, 47]
	Analgesics, opioids	N02A	[10, 11, 14, 17]
	Analgesics, non-opioid	N02B, N02AJ01, N02AJ02, N02AJ03, N02AJ06, N02AJ07, N02AJ09, N02AJ13, N02AJ15, N02AJ17, N02AJ18	[14]
	Antiepileptics	N03	[10, 11, 14, 48]
	Anti-Parkinson agents	N04	[11, 14, 45]
	Anti-dementia agents	N06D	[11, 14, 47]
Others	Urological agents	G04B	[11, 39]
	Benign prostatic hypertrophy agents	G04C	[11, 44]
	Antispasmodics	A03A-A03E, A02AG, N02AG, A06AB3	[39]
	Laxatives	A06A	[11, 14]
	Antacids	A02A	[44, 45]
	H2-receptor antagonists	A02BA	[44–46]
	Proton pump inhibitors	A02BC-A02BD, M01AE52	[11, 44, 46, 49]
	Antidiabetic agents	A10	[11, 14, 44, 45]
	NSAIDs	M01A, N02AJ08, N02AJ14, N02AJ19	[11, 14, 17, 44]
	Muscle relaxants	M03B	[39, 44, 50]
	Corticosteroids (systemic)	H02A	[11, 51]
	Asthma & COPD agents	R03	[40]
	Cough and cold preparations	R05	[52]
	Antihistamines (systemic)	R06	[11, 44, 45]