Table 4.

Odds ratios of FRIs associated medication use in older adults: case-crossover design

Medication class	Subclass of the study medications	Exposed only in the hazard period, n = 94,332		Exposed only in the control period, n = 94,332		Crude OR	95%CI
		N	%	N	%		Lower	Upper
Cardiovascular	Angiotensin II antagonists	2,148	2.3%	1,216	1.3%	1.96	1.79	2.15
	Beta-blocking agents	1,089	1.2%	1,171	1.2%	0.92	0.82	1.03
	Calcium channel blockers	2,231	2.4%	1,698	1.8%	1.38	1.27	1.50
	Diuretics	2,207	2.3%	2,127	2.3%	1.04	0.97	1.13
	Antithrombotic agents	2,204	2.3%	1,530	1.6%	1.54	1.41	1.67
	Lipid-modifying agents	2,370	2.5%	1,727	1.8%	1.46	1.34	1.58
Nervous system	Antipsychotics	420	0.4%	242	0.3%	1.84	1.51	2.25
	Antidepressants	2,110	2.2%	1,581	1.7%	1.37	1.26	1.49
	Anxiolytics	7,010	7.4%	6,159	6.5%	1.15	1.10	1.20
	Hypnotics and sedatives	1,283	1.4%	1,066	1.1%	1.22	1.10	1.35
	Opioids	7,642	8.1%	5,015	5.3%	1.56	1.49	1.63
	Antiepileptics	1,342	1.4%	1,016	1.1%	1.37	1.23	1.52
	Anti-Parkinson agents	259	0.3%	149	0.2%	1.88	1.45	2.43
	Anti-dementia agents	1,072	1.1%	945	1.0%	1.16	1.03	1.30
Others	Benign prostatic hypertrophy agents	1,387	1.5%	1,095	1.2%	1.31	1.18	1.45
	Antacids	8,287	8.8%	8,057	8.6%	1.03	0.99	1.07
	H2-receptor antagonists	11,569	12.3%	10,306	10.9%	1.13	1.09	1.17
	Laxatives	804	0.9%	701	0.7%	1.16	1.02	1.32
	NSAIDs/antirheumatic agents	16,069	17.1%	12,328	13.1%	1.32	1.28	1.36
	Muscle relaxants	10,442	11.1%	6,513	6.9%	1.65	1.59	1.72
	Corticosteroids (systemic)	5,812	6.2%	5,589	5.9%	1.04	1.00	1.09
	Asthma/COPD agents	3,516	3.7%	3,735	4.0%	0.94	0.89	1.00
	Cough and cold preparations	10,691	11.3%	11,923	12.7%	0.89	0.87	0.92
	Antihistamines (systemic)	9,861	10.5%	10,786	11.4%	0.91	0.88	0.94

FRI Fall related injuries, OR Odds ratio