Table 3.
Clinical, laboratory and imaging data of hypertension patients among different antihypertensive targets
| Variables | Intensive Treatment (n = 85) | Standard Treatment (n = 214) | P value a | ||
|---|---|---|---|---|---|
| Pre-treatment | Post-treatment | Pre-treatment | Post-treatment | ||
| Systolic pressure, mmHg | 133.00 [123.00, 147.00] | 112.00 [106.00, 117.00] | 134.00 [126.00, 151.00] | 130.00 [125.00, 134.00] | < 0.001 |
| Diastolic pressure, mmHg | 79.00 [71.00, 87.00] | 73.00 [67.00, 80.00] | 78.00 [70.00, 86.00] | 76.00 [69.25, 83.00] | 0.103 |
| Heart rate, bpm | 72.00 [66.00, 78.25] | 72.00 [66.00, 78.00] | 72.00 [69.00, 78.00] | 74.00 [68.00, 80.00] | 0.398 |
| Laboratory Findings | |||||
| Venous blood glucose, mmol/L | 5.00 [4.69, 5.94] | 5.30 [5.02, 5.90] | 5.20 [4.83, 6.03] | 5.28 [4.93, 6.16] | 0.778 |
| Serum creatinine, μmol/L | 73.80 [61.05, 86.00] | 74.20 [65.47, 92.17] | 70.30 [57.35, 86.90] | 69.40 [58.20, 90.00] | 0.061 |
| Blood urea nitrogen, mmol/L | 5.30 [4.51, 6.12] | 5.78 [4.57, 7.18] | 5.30 [4.45, 6.50] | 5.70 [4.60, 7.13] | 0.857 |
| Uric acid, μmol/L | 353.70 [305.70, 437.00] | 379.10 [314.22, 449.78] | 346.10 [266.75, 430.40] | 351.40 [277.60, 425.10] | 0.011 |
| Calcium ion, mmol/L | 2.24 [2.16, 2.32] | 2.25 [2.17, 2.34] | 2.27 [2.16, 2.36] | 2.25 [2.19, 2.34] | 0.801 |
| Potassium ion, mmol/L | 3.95 [3.74, 4.12] | 3.94 [3.72, 4.15] | 3.87 [3.64, 4.16] | 3.95 [3.70, 4.14] | 0.972 |
| Sodium ion, mmol/L | 140.75 [138.70, 142.35] | 140.00 [138.00, 142.00] | 140.40 [138.60, 141.80] | 140.60 [138.80, 142.20] | 0.248 |
| Total cholesterol, mmol/L | 4.18 [3.68, 4.88] | 3.67 [3.28, 4.27] | 4.56 [3.71, 5.17] | 4.16 [3.32, 5.02] | 0.003 |
| High density lipoprotein, mmol/L | 1.17 [1.01, 1.34] | 1.09 [0.92, 1.27] | 1.14 [0.94, 1.40] | 1.13 [0.93, 1.30] | 0.435 |
| Low density lipoprotein, mmol/L | 2.50 [2.12, 3.12] | 2.13 [1.66, 2.57] | 2.70 [2.14, 3.24] | 2.42 [1.74, 3.18] | 0.014 |
| Triglyceride, mmol/L | 1.33 [1.05, 1.80] | 1.16 [0.84, 1.65] | 1.42 [0.99, 2.01] | 1.29 [0.92, 1.95] | 0.197 |
| Creatine kinase, U/L | 81.00 [66.25, 125.62] | 96.00 [73.25, 131.25] | 89.00 [68.00, 135.25] | 94.00 [66.00, 137.00] | 0.841 |
| Creatine kinase-MB, U/L | 12.00 [10.00, 15.50] | 13.00 [10.00, 20.00] | 12.00 [8.00, 15.75] | 13.00 [10.00, 17.00] | 0.347 |
| Lactate dehydrogenase, U/L | 190.50 [170.25, 218.75] | 190.00 [167.00, 227.75] | 189.00 [167.25, 220.00] | 186.00 [164.00, 211.00] | 0.453 |
| Cardiac troponin I, pg/mL | 3.90 [1.90, 9.15] | 3.60 [1.90, 12.70] | 3.30 [1.90, 8.90] | 3.70 [1.90, 10.10] | 0.958 |
| Pro-brain natriuretic peptide, pg/mL | 79.05 [40.47, 266.00] | 58.10 [24.47, 261.00] | 111.00 [67.75, 312.25] | 99.70 [59.90, 408.50] | 0.014 |
| Echocardiography | |||||
| Ascending aorta diameter, mm | 33.00 [28.25, 34.00] | 32.00 [30.00, 34.00] | 32.00 [29.00, 35.00] | 33.00 [30.00, 35.00] | 0.177 |
| Left atrial diameter, mm | 33.00 [30.00, 36.00] | 34.00 [31.50, 37.50] | 34.00 [31.00, 37.00] | 35.00 [31.00, 39.00] | 0.324 |
| Left ventricular diameter, mm | 43.00 [41.00, 46.00] | 45.00 [41.50, 48.00] | 44.00 [41.00, 47.25] | 44.50 [42.00, 48.00] | 0.957 |
| Ventricular septal thickness, mm | 11.00 [10.00, 12.00] | 11.00 [10.00, 12.00] | 11.00 [10.00, 12.00] | 11.00 [10.00, 12.00] | 0.855 |
| Pulmonary artery diameter, mm | 24.00 [23.00, 25.50] | 24.00 [22.00, 25.75] | 24.00 [23.00, 26.00] | 24.00 [21.00, 26.00] | 0.881 |
| LVEF, (%) | 66.00 [61.50, 71.00] | 65.00 [59.00, 69.00] | 65.00 [61.00, 70.00] | 63.00 [59.00, 68.00] | 0.662 |
| Severe valve regurgitation, n (%) | 13 (15.29) | 26 (30.59) | 39 (18.22) | 77 (35.98) | 0.453 |
| Severe valve calcification, n (%) | 12 (14.12) | 17 (20.00) | 31 (14.49) | 46 (21.50) | 0.898 |
| Complications | |||||
| Diabetes, n (%) | 15 (17.65) | 24 (28.24) | 38 (17.76) | 50 (23.36) | 0.464 |
| Hyperlipidemia, n (%) | 13 (15.29) | 22 (25.88) | 45 (21.03) | 62 (28.97) | 0.694 |
| Treatments | |||||
| Single-drug, n (%) | 28 (32.94) | 84 (39.25) | 0.565 | ||
| Two-drug, n (%) | 39 (45.88) | 92 (42.99) | |||
| Multi-drug, n (%) | 18 (21.18) | 38 (17.76) | |||
| Clinical outcomes | 21 (24.71) | 86 (40.19) | 0.017 | ||
NA Not available. P values < 0.05 are written in italics
Values shown are mean ± SD, median (interquartile range [IQR]) or n (%). P values were calculated by chi-squared test, Fisher’s exact test, t test, or Mann–Whitney U test, as appropriate
Abbreviations: n Number, LVEF Left ventricular ejection fraction
aStatistical difference between the intensive group and standard group after treatment