Skip to main content
. Author manuscript; available in PMC: 2023 Jul 23.
Published in final edited form as: Brain Behav Immun. 2023 May 5;111:298–311. doi: 10.1016/j.bbi.2023.04.013

Figure 2.

Figure 2.

Intrathecal injection of human CS (hCS, from a male doner) alleviates neuropathic pain symptom following PTX-induced CIPN in male mice. (A, B) Von Frey tests for mechanical pain showing paw withdrawal threshold (PWT, A) and paw withdrawal frequency (PWF, B). (C) Acetone test showing cold pain. (D) Open-field test in hCS and hNCS treated animals. hCS produces long-term reduction of PTX-induced mechanical allodynia by increasing PWT (A) and decreasing PWF (B), without effects on cold pain (C) and motor function (D). n=5 male mice per group. *p<0.05, **p<0.01, ***p<0.001, two-way ANOVA, followed by Bonferroni posthoc test. hCS, human conditioned serum; hNCS, human non-conditioned serum.