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. Author manuscript; available in PMC: 2023 Jul 23.
Published in final edited form as: Brain Behav Immun. 2023 May 5;111:298–311. doi: 10.1016/j.bbi.2023.04.013

Figure 3.

Figure 3.

Intrathecal human CS (hCS, from a male donor) treatment significantly improves nerve conduction velocity in male and female mice with CIPN. (A) Schematic of sensory conductance measurement. Two stimulation electrodes were inserted into a hind paw with 1 cm between them and the recording cuff electrode was inserted to the sciatic nerve (1 ms stimulation 10V). (B) Representative nerve conductance trace. left: control mice. right: hCS-treated mice. (C,D) Quantification of nerve conductance velocity (C) and amplitude (D). n = 7 mice for naïve control, n = 5 mice for hNCS with PTX, n = 7 mice for hCS with PTX. *p<0.05, Unpaired t-test.