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. Author manuscript; available in PMC: 2023 Jul 23.
Published in final edited form as: Brain Behav Immun. 2023 May 5;111:298–311. doi: 10.1016/j.bbi.2023.04.013

Figure 7.

Figure 7.

Anti-TGF-β1 and anti-IL1ra neutralizing antibodies transiently reverses the anti-allodynic effects of rCS in mice. (A, B) Von Frey tests for PWT (A) and PWF (B) showing a temporary reversal of hCS-induced analgesia at 1 hour post-injection with 4 μg of anti-TGF-β1 antibody. (C, D) Von Frey tests for PWT (C) and PWF (D) showing a temporary reversal of rCS-induced analgesia at 1-3 h post-injection with 4 μg of anti-IL-1ra antibody. Intrathecally-injected IgG was included as control. *p<0.05, **p<0.01, ***, p<0.001, n=5 per group, two-way ANOVA, followed by Bonferroni posthoc test. Male donors and receivers were tested.