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. Author manuscript; available in PMC: 2024 Jul 11.
Published in final edited form as: Chem Commun (Camb). 2023 Jul 11;59(56):8692–8695. doi: 10.1039/d3cc01945d

Fig. 1.

Fig. 1.

Model for enhanced cell penetration of boronic acid containing ASOs. (A) Enhanced internalization of 5boU-containing nucleic acids is envisioned to occur via reversible covalent linking with cell-surface glycans, as previously described for boronate-containing peptides and proteins.8, 9 (B) Schematic showing chloroalkane penetration assay (CAPA). (C) Structure of test compounds consisting of a druglike ASO, variable 5boU moieties, a linker, and a HaloTag substrate. ct-ASO: chloroalkane-tagged antisense oligonucleotide.