Table 3.
Properties of General Anesthetic Nanomedicines
Nanomedicine | Particle Size | Carrier Material | Effect | References |
---|---|---|---|---|
Propofol nanoparticles | 180±1.2 nm | Octanol-alginate nanoparticles | – | [82] |
Propofol nanodroplets | 317.6±148.2 nm | Polyethylene glycol-b-polycaprolactone and perfluorocarbon | Ultrasound can double the rate of drug release | [83] |
Propofol loaded propionylated amylose helix | 55 ± 12 nm | Propionylated amylose helix | The induction time was 0.22 times of that the propofol emulsion group; The recovery time was 0.20 times that of the propofol emulsion group |
[84] |
PROP- GQY, ET-GQY, ET26-GQY | 165.6±11.93nm | Peptide GQY | GQY can be used as a high loading fat-free carrier material | [85] |
126–138 nm | Hemifluorinated dibranched polymers | – | [86] | |
Propofol-LCNP | ≈200m | Self-assembled lipid liquid crystalline | – | [87] |
Eto-SOPM | 109.23±0.81nm | Poloxamer micelles | The rats recovered from the loss of righting reflex 10% faster than the free group | [88] |
ETM-ILE | 168.0±0.3nm | Lipid | – | [89] |
Abbreviations:GQY, Gly-Gln-Tyr; PROP, propofol; ET, etomidate; ET26, an analog of etomidate; LCNP, Liquid crystalline nanoparticles; Eto-SOPM, etomidate-loaded poloxamer micelles; ETM-ILE, etomidate intravenous lipid emulsion.