Table 1.
Clinical Characteristics of 128 Patients with High and Low NK Cell Count at 30 Days After HSCT
| NK30 >165/µL n=74 | NK30≤165/µL n=54 | P | |
|---|---|---|---|
| Age, years | 34.5(18–69) | 31(18–64) | 0.156 |
| Sex | 0.805 | ||
| Male | 40 | 28 | |
| Female | 34 | 26 | |
| Disease | 0.824 | ||
| AML | 35 | 27 | |
| ALL | 28 | 21 | |
| MDS | 11 | 6 | |
| Risk stratification | 0.169 | ||
| Standard risk | 42 | 24 | |
| High risk | 32 | 30 | |
| Pre-MRD | 0.782 | ||
| Positive | 27 | 21 | |
| Negative | 47 | 33 | |
| Blood-type match | 0.545 | ||
| Matched | 41 | 27 | |
| Mismatched | 33 | 27 | |
| Donor type | 0.083 | ||
| MSD | 32 | 18 | |
| HID | 38 | 36 | |
| MUD | 4 | 0 | |
| ATG in conditioning | 0.086 | ||
| Positive | 44 | 40 | |
| Negative | 30 | 14 | |
| Graft dose, median (range) | |||
| MNC (×108/kg) | 9.44(4.86–22.01) | 9.54(5.84–19.09) | 0.739 |
| CD34+ cell (×106/kg) | 4.36(2.26–8.59) | 4.00(1.58–8.83) | 0.372 |
| Engraftment time, median (range) | |||
| Granulocyte, days | 11(9–20) | 12.5(8–25) | 0.136 |
| PLT, days | 15(8–29) | 16(8–24) | 0.854 |
Notes: Standard risk was defined according to the European Group for Blood and Marrow Transplantation criteria as early and intermediate risk scores; high risk was defined as late risk score. MRD was assessed in all patients by flow cytometry, karyotyping, and quantitative PCR.
Abbreviations: Pre-MRD, MRD before transplantation; HID, haplo-identical donor; MSD, matched sibling donor; MUD, matched unrelated donor; MNC, mononuclear cell; PLT, platelet, HSCT, Haematopoietic stem cell transplantation; MRD, Minimal residual disease; ATG, Anti-thymocyte globulin; AML, Acute myeloid leukemia; ALL, Acute lymphoblastic leukemia; MDS, Myelodysplastic syndromes.