Table 2.
Univariate Analysis of Factors Associated with OS and RFS After HSCT
| Variate | OS | RFS | ||
|---|---|---|---|---|
| P | HR (95% CI) | P | HR (95% CI) | |
| Age | 0.801 | 1.00(0.97–1.04) | 0.83 | 0.99(0.97–1.02) |
| Sex | 0.867 | 1.06(0.51–2.21) | 0.48 | 1.24(0.69–2.24) |
| Disease | 0.229 | 0.61(0.27–1.37) | 0.28 | 0.70(0.37–1.33) |
| Disease risk (standard vs high) | 0.018 | 2.58(1.18–5.68) | 0.04 | 1.87(1.02–3.43) |
| Pre-MRD (negative vs positive) | <0.01 | 4.31(1.96–9.47) | <0.01 | 3.13(1.71–5.72) |
| ATG in conditioning (negative vs positive) | 0.348 | 1.48(0.65–3.33) | 0.54 | 0.83(0.45–1.52) |
| HLA match (matched vs haplo-matched) | 0.409 | 0.74(0.35–1.53) | 0.16 | 0.66(0.36–1.18) |
| Blood-type match (matched vs mismatched) | 0.643 | 1.19(0.57–2.46) | 0.46 | 1.25(0.69–2.26) |
| NK30 (low vs high) | 0.001 | 0.28(0.13–0.61) | 0.016 | 0.48(0.26–0.88) |
| NK60 (low vs high) | 0.008 | 0.33(0.15–0.76) | 0.032 | 0.51(0.27–0.95) |
| Graft dose | ||||
| CD34+cell | 0.071 | 0.79(0.61–1.02) | 0.085 | 0.84(0.68–1.03) |
| MNC | 0.053 | 0.86(0.74–1.00) | 0.025 | 0.87(0.77–0.98) |
| CD3+T30 | 0.133 | 0.99(0.99–1.00) | 0.181 | 0.99(0.99–1.00) |
| CD4+T30 | 0.445 | 0.99(0.99–1.00) | 0.734 | 1.00(0.99–1.00) |
| CD8+T30 | 0.138 | 0.99(0.99–1.00) | 0.101 | 0.99(0.99–1.00) |
Abbreviations: OS, Overall survival; RFS, Relapse-free survival; HSCT, Haematopoietic stem cell transplantation; MRD, Minimal residual disease; HR, Hazard ratio; ATG, Anti-thymocyte globulin; HLA, Human leukocyte antigens; MNC, Mononuclear cell.