Table 4.

Univariate and Multivariate Cox Regression Models Incorporating Prognostic Risk Models and NLR in Prediction of Cancer-Specific Survival, and Overall Survival

Variable	Cancer-Specific Survival				Overall Survival
	Univariate Model		Multivariate Model		Univariate Model		Multivariate Model
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
UISS risk group
Low	Reference		Reference		Reference		Reference
Intermediate	5.03 (1.43–17.68)	0.012*	4.82 (1.37–16.92)	0.014*	2.97 (1.24–7.12)	0.015*	2.92 (1.22–7.00)	0.016
High	30.42 (8.65–106.93)	<0.001*	29.03 (8.22–102.53)	<0.001*	13.39 (5.33–33.63)	<0.001*	13.01 (5.16–32.81)	<0.001*
NLR		<0.001*		<0.001*
<3.4	Reference		Reference		Reference		Reference
≥3.4	7.14 (3.40–15.02)		6.72 (3.16–14.28)		5.28 (2.69–10.35)	<0.001*	5.09 (2.58–10.03)	<0.001*
SSIGN risk group
Low	Reference		Reference		Reference		Reference
Intermediate	9.78 (4.28–22.39)	<0.001*	8.45 (3.67–19.44)	<0.001*	5.78 (2.95–11.34)	<0.001*	5.22 (2.65–10.28)	<0.001*
High	36.27 (11.95–110.06)	<0.001*	27.46 (8.96–84.15)	<0.001*	15.94 (5.30–47.92)	<0.001*	12.22 (4.03–37.10)	<0.001*
NLR
<3.4	Reference		Reference		Reference		Reference
≥3.4	7.14 (3.40–15.02)	<0.001*	5.08 (2.40–10.78)	<0.001*	5.28 (2.69–10.35)	<0.001*	4.17 (2.11–8.25)	<0.001*

Note: *Statistically significant.

Abbreviations: HR (95% CI), Hazard Ratio (95% confidence interval); NLR, Neutrophil-to-Lymphocyte Ratio; UISS, University of California, Los Angeles, integrated staging system; SSIGN, the stage, size, grade, and necrosis (SSIGN) score.