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. 2023 Jul 19;18:3951–3972. doi: 10.2147/IJN.S410996

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© 2023 He et al.

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Assessment of the biofilm-dispersion activity of electrospun nanofibers in vivo. (A) Illustration of the biofilm-dispersion assay. (B and C) SEM observation of the remaining biofilm (ATCC 43300) on skin wounds when cultured with the electrospun sustained-release nanosystems at preset time points. White arrows indicate the bacteria remaining in the skinfolds. (D and E) Bacterial colonization in the skin tissues on days 1 and 3. n = 5, *P < 0.05 TTO-NL@PCS vs TTO@PCS, ^#P < 0.05 TTO@PCS vs NC, n.s. = no significance PCS vs NC.