FIGURE 5.

SIRT5 affects proteins involved in Parkinson’s disease. (A, B) ClueGO [57] KEGG pathway enrichment and network analysis of SIRT5-regulated malonyl (A) and succinyl (B) proteins. Pathway-connecting edges represent Kappa score above 40%. Same color pathways have at least 50% similarity. Pathways are listed in Table S8E. Neurogenerative diseases: pathways of ND, pathways of neurodegeneration, ALS, AD, HD, PD, Prion (prion disease), and NAFLD. (C) Extracted ion chromatograms of VE¹⁴⁸KsuccDGLILTSR (m/z 665.86, z = 2+) of the protein deglycase DJ-1 (PARK7). AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; HD, Huntington’s disease; NAFLD, non-alcoholic fatty liver disease; PD, Parkinson’s disease