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Mechanistic comparison between TBI-induced and hemorrhagic shock-induced microvascular dysfunction
| Pathology | TBI | HS |
|---|---|---|
| Excessive hyperadhesive VWF | X | X |
| Low ADAMTS13 | X | X |
| Hyper-to-hypocoagulation (56) | X | X |
| Pathologic EVs | X | ? |
| Syndecan-1 shedding to expose ECs | X | X |
TBI indicates traumatic brain injury; VWF, von Willebrand factor.
