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Comparison of the cryo-EM structure of paclitaxel bound to tubulin with a model of PB-Gly-Taxol docked to tubulin. (A) Paclitaxel bound to β-tubulin (PDB ID: 3J6G). (B) A pose of PB-Gly-Taxol docked to the Taxol binding site (AutoDock Vina). Pacific Blue may engage a pocket adjacent to the Taxol binding site to enhance affinity.
