Figure 6.
Analysis of uptake of PB-Gly-Taxol and PB-GABA-Taxol by trypsinized Caco-2 wild-type, MDR1 (−/−/−/−), and MDR1/MRP2 (−/−/−/−,−/−/−/−) cell lines by flow cytometry. Cells were treated with PB-Taxoids (1 μM) and DMSO vehicle (0.2%) or efflux inhibitors (verapamil (100 μM), probenecid (10 mM), and KO143 (10 μM)) for 1 h. Error bars = SD, n=3.