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. 2015 Feb 12;2015(2):CD000184. doi: 10.1002/14651858.CD000184.pub4

Comparison 2. Tocolytic drug 1 (A) vs tocolytic drug 2 (A).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Cephalic presentation at birth (primary) 2   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.1 Calcium channel blockers (A2) vs beta stimulants (A1) 1 90 Risk Ratio (M‐H, Random, 95% CI) 0.62 [0.39, 0.98]
1.2 Nitric oxide donors (A3) vs beta stimulants (A1) 1 74 Risk Ratio (M‐H, Random, 95% CI) 0.56 [0.29, 1.09]
1.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
2 Failure to achieve cephalic vaginal birth (composite outcome: caesarean section + vaginal breech birth) 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.1 Calcium channel blockers (A2) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
2.2 Nitric oxide donors (A3) vs beta stimulants (A1) 1 74 Risk Ratio (M‐H, Random, 95% CI) 1.13 [0.88, 1.47]
2.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
3 Caesarean section (primary) 2   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
3.1 Calcium channel blockers (A2) vs beta stimulants (A1) 2 170 Risk Ratio (M‐H, Random, 95% CI) 1.28 [1.03, 1.59]
3.2 Nitric oxide donors (A3) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
3.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
4 Fetal bradycardia (primary) 3   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
4.1 Calcium channel blockers (A2) vs beta stimulants (A1) 2 170 Risk Ratio (M‐H, Random, 95% CI) 1.17 [0.46, 3.03]
4.2 Nitric oxide donors (A3) vs beta stimulants (A1) 1 74 Risk Ratio (M‐H, Random, 95% CI) 1.06 [0.16, 7.10]
4.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
5 Failed external cephalic version 4   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
5.1 Calcium channel blockers (A2) vs beta stimulants (A1) 2 176 Risk Ratio (M‐H, Random, 95% CI) 1.41 [1.06, 1.86]
5.2 Nitric oxide donors (A3) vs beta stimulants (A1) 2 133 Risk Ratio (M‐H, Random, 95% CI) 1.48 [1.13, 1.94]
5.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
6 Difficult external cephalic version 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
6.1 Calcium channel blockers (A2) vs beta stimulants (A1) 1 90 Risk Ratio (M‐H, Random, 95% CI) 5.22 [0.26, 105.81]
6.2 Nitric oxide donors (A3) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
6.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
7 Maternal palpitations 2   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
7.1 Calcium channel blockers (A2) vs beta stimulants (A1) 1 86 Risk Ratio (M‐H, Random, 95% CI) 0.8 [0.23, 2.78]
7.2 Nitric oxide donors (A3) vs beta stimulants (A1) 1 74 Risk Ratio (M‐H, Random, 95% CI) 0.53 [0.10, 2.71]
7.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
8 Maternal headaches 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
8.1 Calcium channel blockers (A2) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
8.2 Nitric oxide donors (A3) vs beta stimulants (A1) 1 74 Risk Ratio (M‐H, Random, 95% CI) 3.52 [1.05, 11.76]
8.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
9 Maternal hypotension 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
9.1 Calcium channel blockers (A2) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
9.2 Nitric oxide donors (A3) vs beta stimulants (A1) 1 74 Risk Ratio (M‐H, Random, 95% CI) 3.17 [0.35, 29.06]
9.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
10 Operative vaginal birth 0   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
10.1 Calcium channel blockers (A2) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
10.2 Nitric oxide donors (A3) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
10.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
11 Maternal mortality 0   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
11.1 Calcium channel blockers (A2) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
11.2 Nitric oxide donors (A3) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
11.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
12 Maternal morbidity 0   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
12.1 Calcium channel blockers (A2) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
12.2 Nitric oxide donors (A3) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
12.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
13 Perinatal mortality 0   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
13.1 Calcium channel blockers (A2) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
13.2 Nitric oxide donors (A3) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
13.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
14 Perinatal morbidity 0   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
14.1 Calcium channel blockers (A2) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
14.2 Nitric oxide donors (A3) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
14.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
15 Vaginal breech birth (not prespecified) 0   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
15.1 Calcium channel blockers (A2) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
15.2 Nitric oxide donors (A3) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
15.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
16 Apgar < 7 at 5 minutes (not prespecified) 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
16.1 Calcium channel blockers (A2) vs beta stimulants (A1) 1 89 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
16.2 Nitric oxide donors (A3) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
16.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
17 Neonatal seizures (not prespecified) 0   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
17.1 Calcium channel blockers (A2) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
17.2 Nitric oxide donors (A3) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
17.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
18 Admissions to neonatal unit (not prespecified) 1 86 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
18.1 Calcium channel blockers (A2) vs beta stimulants (A1) 1 86 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
18.2 Nitric oxide donors (A3) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
18.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
19 Birth trauma (not prespecified) 0   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
19.1 Calcium channel blockers (A2) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
19.2 Nitric oxide donors (A3) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
19.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
20 Maternal flushing (not prespecified) 0   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
20.1 Calcium channel blockers (A2) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
20.2 Nitric oxide donors (A3) vs beta stimulants (A1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
20.3 Nitric oxide donors (A3) vs calcium channel blockers (A2) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]