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Serum VRC01 concentration (log10) kinetics between cohorts and across infusion intervals. Antibody concentrations per participant are shown over time since enrolment by dose group (10 mg/kg and 30 mg/kg) and case–control status (acquired HIV-1/without HIV-1) in (a) HVTN 704/HPTN 085 (n = 104) and (b) HVTN 703/HPTN 081 (n = 91). Red symbols and lines indicate VRC01 recipients that acquired HIV-1 and blue lines and symbols indicate VRC01 recipients without HIV-1.
