Fig. 4.

VRC01 concentrations over-time in VRC01 recipients who acquired HIV-1 and VRC01 recipients without HIV-1. Geometric mean VRC01 serum concentrations in the low dose (10 mg/kg) and high dose (30 mg/kg) in HVTN 703/HPTN 081 (top panels) and HVTN 704/HPTN 085 (lower panels) through week 80 post enrolment. VRC01 recipients who acquired HIV-1 (n = 107) are indicated in red curves, with open red circles. VRC01 recipients without HIV-1 (n = 82) are indicated in blue curves. For each VRC01 recipient without HIV-1, their geometric mean concentration calculated across the grid of daily concentration values through week 80 was used in the calculation. For each VRC01 recipient who acquired HIV-1, their estimated concentration at the estimated date of HIV-1 acquisition was used in the calculation.