Fig. 3.

B-cell phenotype of HEI and HEU in the first 2 years of life. Bar plot in figure A shows the number of B-cell phenotype features (subsets) which resulted significantly different after Bonferroni correction (adj. p-value < 0.05) between HEU and HEI at each time point. Violin plots in panel B and C show the main distinctive features between HEU and HEI at entry, with mean values as black dotted lines. Principal component analysis (PCA) analyzing the B-cell phenotype at entry in HEU and HEI is shown in panel D. The first 10 top loading features contributing to PC4 and PC5 are shown in panel E.