Fig. 2.

Overexpression of circRNA Galntl6 in RVLM improved SIH. (A) Radio telemetry was used to measure the MAP and HR in rats after circRNA Galntl6 overexpression. (B and C) Effects of circRNA Galntl6 overexpression on the sympathetic outflow were unveiled using RSNA recording test and plasma NE ELISA. (D) RVLM neuronal excitability was detected by immunostaining with c-Fos. Data were expressed as mean ± SEM. Statistical significance was determined by one-way ANOVA, followed by post-hoc Bonferroni test (A–D). n = 6 rats per group (A–D). *p < 0.05, ***p < 0.001, and ns means nonsignificant versus SIH group.