Fig. 5.

CircRNA Galntl6 repressed oxidative stress in RVLM of SIH rats by binding to miR-335. (A–C) Effects of circRNA Galntl6 overexpression and miR-335 agomir on the level of 8-OH-dG and activities of SOD and CAT in RVLM were measured using commercial kits. (D) Influences of circRNA Galntl6 upregulation and miR-335 agomir on ROS production in RVLM were detected by DHE staining. Data were expressed as mean ± SEM. Statistical significance was determined by one-way ANOVA, followed by post-hoc Bonferroni test (A–D). n = 6 rats per group (A–D). *p < 0.05, **p < 0.01, ***p < 0.001, and ns means nonsignificant versus SIH group.