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. 2023 Jun 9;64:102782. doi: 10.1016/j.redox.2023.102782

Fig. 8.

Fig. 8

CircRNA Galntl6 regulated Lig3 expression via targeting miR-335. (A and B) Effects of circRNA Galntl6 overexpression and miR-335 agomir on the expression of Lig3 were revealed using RT-qPCR and Western blot analyses in B104 cells. (C and D) RT-qPCR and Western blot assays were used to illustrate the effects of circRNA Galntl6 knockdown and miR-335 antagomir on Lig3 expression in B104 cells. (E and F) After microinjection of pLV-circRNA Galntl6 plasmid and miR-335 agomir into RVLM of SIH rats, the expression of Lig3 was measured by RT-qPCR and Western blot analyses. Data were expressed as mean ± SEM. Statistical significance was determined by one-way ANOVA, followed by post-hoc Bonferroni test (A–F). n = 6 of independent cell culture preparations (A and C). n = 3 of independent cell culture preparations (B and D). n = 6 rats per group (E). n = 3 rats per group (F). #p < 0.05, ##p < 0.001, and ns means nonsignificant versus pLV-NC group. Δp< 0.05, ΔΔΔp< 0.001, and ns means nonsignificant versus si-NC group. *p < 0.05, ***p < 0.001, and ns means nonsignificant versus SIH + pLV-NC group.