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. 2023 Jun 7;93:104642. doi: 10.1016/j.ebiom.2023.104642

Fig. 4.

Fig. 4

Semaglutide enhances dopamine metabolism in nucleus accumbens when alcohol is onboard. The in vivo microdialysis experiment reveals that the (A) DOPAC and (B) HVA levels in nucleus accumbens (NAc) shell are higher in male mice treated with the combination of semaglutide and alcohol compared to those treated with only alcohol (n = 12 for vehicle–vehicle, n = 18 for vehicle-alcohol, n = 12 for semaglutide-vehicle, n = 15 for semaglutide-alcohol; two-way ANOVA with repeated measures). These results indicate that semaglutide enhances the metabolism of dopamine when alcohol is onboard. In support, the NAc gene expression of (C) MAOA and (D) COMT, but not (E) MAOB and (F) DAT, is higher in male mice treated with both semaglutide and alcohol compared to those treated with alcohol (n = 5 for both treatment groups, unpaired t-test). Experiments were not replicated. Data are presented as mean ± SEM, significant data are illustrated by ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 in comparison to vehicle treatment; +P < 0.05, ++P < 0.01, +++P < 0.001 when comparing alcohol treatment to the combination of semaglutide and alcohol.