Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic model depicting that UCKL1 regulates ferroptosis by modulating Nrf2-SLC7A11 axis. UCKL1 stabilizes Nrf2, which in turn promotes the expression of SLC7A11. UCKL1 knockdown reduces the expression of SLC7A11 and results with ferroptosis. Targeting UCKL1 synergizes with GPX4 inhibitors thereby inhibit CRC growth via induction of ferroptosis.
