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. 2023 Jun 9;64:102781. doi: 10.1016/j.redox.2023.102781

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Upstream and downstream effectors of Nox4 involved in diabetic microvascular complications exposed to high glucose and diabetes. Abbreviations: HIF-1: hypoxia inducible factor-1; ChREBP: carbohydrate-responsive element-binding protein; PKC: protein kinase C; TXNIP: thioredoxin interacting protein; FOXP1: forkhead box prote1; Cx32: Connexin 32; TRPC6: transient receptor potential channel 6; AMPK: AMP-activated protein kinase; CYP4A: 4A family cytochrome P450; MIOX: Myo-Inositol Oxygenase; Egr1: early growth response 1; VEGF: vascular endothelial growth factor; Ang II: angiotensin II; TGF-β: transforming growth factor-β; LXR: liver X receptor.