Table 1.
Cohort demographic comparisons [median, interquartile range].
| HC | S0 | S1 | S2 | S3 | χ2, p | |
|---|---|---|---|---|---|---|
| n | 50 | 50 | 64 | 63 | 63 | |
| Age [years] | 57.5, 37.8–65.0 | 35.0, 30.5–40.0 | 45.5, 37.3–58.0 | 56.0, 49.0–65.0 | 56.0, 47.0–65.0 | 80.3, <0.0001 |
| Gender n[F/M] | 22/28 | 27/23 | 31/33 | 24/39 | 34/29 | 4.45, 0.35 |
| Education [years] | 16.0, 13.8–16.3 | 16.0, 13.5–16.5 | 16.0, 14.0–17.0 | 16.0, 13.0–18.0 | 14.0, 12.0–17.0 | 7.7, 0.10 |
| CAG | NA | 40.0, 40.0–42.0 | 42.0, 40.0–43.8 | 42.0, 41.0–43.0 | 43.0, 41.0–46.0 | 31.2, <0.0001 |
| DCL | NA | 0.0, 0.0–0.0 | 1.0, 0.0–3.0 | 4.0, 2.0–4.0 | 4.0, 4.0–4.0 | 145.6, <0.0001 |
| MoCA | 28.0, 27.0–29.0 | 28.0, 27.0–29.0 | 27.0, 26.0–28.0 | 26.0, 24.0–28.0 | 22.0, 18.0–26.0 | 90.5, <0.0001 |
| MMSE | 29.0, 28.0–30.0 | 29.0, 28.0–29.3 | 28.0, 26.0–29.0 | 28.0, 26.0–29.0 | 24.0, 22.0–27.0 | 81.0, <0.0001 |
| cUHDRS | 17.3, 16.5–18.0 | 18.0, 17.1–18.8 | 16.3, 15.8–17.3 | 14.4, 13.6–16.1 | 9.2, 6.9–10.7 | 201.1, <0.0001 |
HC, healthy controls; S0–S3, Stage 0–Stage 3; DCL, Diagnostic Confidence Level; MoCA, Montreal Cognitive Assessment; MMSE, Mini-Mental State Examination; cUHDRS, composite Unified Huntington’s Disease Rating Scale; NA, not applicable. All continuous analyses conducted using Kruskal–Wallis test; comparison of gender proportions conducted using a Chi Square test.