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. 2023 Jun 7;93:104644. doi: 10.1016/j.ebiom.2023.104644

Fig. 3.

Fig. 3

Reduced TIL numbers in intraindividual melanoma metastases. (a) Microphotograph showing a primary cutaneous melanoma with an eTIL score of 30.2% (left) and the matched metastasis from the same patient with an eTIL score of 16.2% (right). (b) Dot plot showing the eTILs of primary and metastatic tumours. Each line represents one patient. The Wilcoxon matched-pairs signed-rank test was statistically significant for a decrease in the eTILs from matched primary to metastatic samples (p < 0.0001). (c) Dot plot showing the eTILs of primary and matched in-transit metastases (Wilcoxon matched-pairs signed-rank test, p = 0.0002). (d) Dot plot showing the eTILs of primary and matched lymph node metastases (Wilcoxon matched-pairs signed-rank test, p = 0.0957). (e) Dot plot showing the eTILs of primary and matched distant metastases (Wilcoxon matched-pairs signed-rank test, p = 0.0266); ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.