Table 1.
Baseline patient clinicopathological characteristics according to the eTILs grouped by the cut-off 16.6%.
| Characteristics |
eTILs ≤16.6% |
eTILs >16.6% |
p value |
|---|---|---|---|
| n = 321 (100%) | n = 98 (30.5%) | n = 223 (69.5%) | |
| eTILs (%) | <0.0001 | ||
| Median [IQR] | 11 [6.9–14.5] | 28 [21.5–36.4] | |
| Age at Dx (y) | 0.0775 | ||
| Median [IQR] | 68 [57–78] | 66 [55–75] | |
| Age group at Dx (y), n (%) | 0.1385 | ||
| ≤65 | 40 (26.5) | 111 (73.5) | |
| >65 | 58 (34.1) | 112 (65.9) | |
| Sex, n (%) | 0.7735 | ||
| Female | 43 (31.4) | 94 (68.6) | |
| Male | 55 (29.9) | 129 (70.1) | |
| Localisation, n (%) | 0.1808 | ||
| Head and neck | 17 (26.6) | 47 (73.4) | |
| Trunk | 34 (28.8) | 84 (71.2) | |
| Upper extr. | 8 (21.6) | 29 (78.4) | |
| Lower extr. | 39 (38.2) | 63 (61.8) | |
| Histological subtypea, n (%) | 0.0055 | ||
| SSM | 42 (26.9) | 114 (73.1) | |
| NM | 31 (49.2) | 32 (50.8) | |
| LMM | 5 (19.2) | 21 (80.8) | |
| ALM | 17 (36.2) | 30 (63.8) | |
| Unknown | 3 (10.3) | 26 (89.7) | |
| BRAF V600 oncogenic varianta, n (%) | 0.2902 | ||
| No | 38 (25.7) | 110 (74.3) | |
| Yes | 21 (37.5) | 35 (62.5) | |
| Unknown | 39 (33.3) | 78 (66.7) | |
| Stage at Dx, n (%) | 0.3366 | ||
| I | 37 (27.6) | 97 (72.4) | |
| II | 61 (32.6) | 126 (67.4) | |
| Substage at Dx, n (%) | 0.0058 | ||
| IA | NA | NA | |
| IB | 37 (27.6) | 97 (72.4) | |
| IIA | 20 (22.7) | 68 (77.3) | |
| IIB | 20 (33.9) | 39 (66.1) | |
| IIC | 21 (52.5) | 19 (47.5) | |
| Tumour thickness (mm) | 0.0036 | ||
| Median [IQR] | 2.78 [1.55–5] | 2 [1.4–3.22] | |
| Tumour thickness group (mm), n (%) | 0.0082 | ||
| ≤1 | NA | NA | |
| 1.1–2.0 | 40 (25.2) | 119 (74.8) | |
| 2.1–4.0 | 30 (29.4) | 72 (70.6) | |
| >4 | 28 (46.7) | 32 (53.3) | |
| Ulceration, n (%) | 0.1740 | ||
| No | 61 (28.1) | 156 (71.9) | |
| Yes | 37 (35.6) | 67 (64.4) | |
| Regressiona, n (%) | 0.1051 | ||
| No | 64 (33.2) | 129 (66.8) | |
| Yes | 17 (23) | 57 (77) | |
| Unknown | 17 (31.5) | 37 (68.5) | |
| Survival (%) | |||
| 5-year RFS | 48.5 | 69.5 | 0.0012 |
| 5-year DMFS | 68.2 | 86.8 | 0.0007 |
| 5-year OS | 76.6 | 87.7 | 0.0226 |
Values are reported as counts (n) and percentages (%) for discrete values and as a median and interquartile range [IQR] for continuous values; for comparisons between categorical variables, Pearson's chi-squared test was used; for comparisons between a continuous and a categorical value, the Mann–Whitney U test was used; for comparisons of survival rates simple cox proportional hazards model was used; RFS, Relapse-free survival; DMFS, Distant metastasis-free survival; OS, Overall survival; SSM, Superficial spreading melanoma; NM, Nodular melanoma; LMM, Lentigo malignant melanoma; ALM, Acrolentiginous melanoma; y, Years; extr., Extremities; Dx, Diagnosis; CI, Confidence interval; NA, Not applicable.
Patients for whom information was unknown were not used for comparisons; significant p values are in bold.