Table 2.
Simple and multiple Cox proportional hazards models for the 5-year RFS with eTILs as a categorical variable.
| Simple cox model |
Multiple cox model |
|||||||
|---|---|---|---|---|---|---|---|---|
| B | SE (B) | HR (95% CI) | p value | B | SE (B) | HR (95% CI) | padj value | |
| Tumour thickness (mm) | ||||||||
| 1.1–2.0 | – | <0.0001 | – | 0.0002 | ||||
| 2.1–4.0 | 0.83 | 0.24 | 2.3 (1.4–3.7) | 0.0004 | 0.73 | 0.24 | 2.08 (1.3–3.4) | 0.0027 |
| >4.0 | 1.37 | 0.25 | 3.93 (2.4–6.3) | <0.0001 | 1.1 | 0.27 | 3 (1.8–5.1) | <0.0001 |
| Ulceration | ||||||||
| No | – | – | ||||||
| Yes | 0.75 | 0.19 | 2.11 (1.4–3.1) | 0.0001 | 0.37 | 0.22 | 1.44 (0.95–2.2) | 0.0894 |
| eTIL score (%) | ||||||||
| ≤16.6 | 0.64 | 0.19 | 1.9 (1.3–2.8) | 0.0012 | 0.48 | 0.2 | 1.62 (1.1–2.4) | 0.0159 |
| >16.6 | – | – | ||||||
HR, Hazard ratio; CI, Confidence interval; SE, Standard error; p-values included in the model were calculated by the Wald test for each variable by dividing the coefficient by its standard error; statistically significant results are reported in bold.