Fig. 1.
Structure of cardiolipin. Cardiolipin possesses a distinctive structure consisting of dimeric phospholipids linked by a glycerol moiety at the head group. The predominant acyl chain constituent of mammalian cardiolipin in cells of natural organisms is linoleic acid (18:2ω6). At neutral pH, cardiolipin exhibits a single positive charge, as a single proton becomes sequestered within a bicyclic resonance structure generated by the two phosphates and the central hydroxyl group.