Fig. 10.

Metformin and A769662 reverse MGO-induced changes of retinal morphology.

Aestheticized mice were intravitreally injected with PBS (n = 10), MGO (1.5 nmol) (n = 10), metformin (5 μg) (n = 10), metformin (5 μg) + MGO (1.5 nmol) (n = 10), A769662 (20 pmol) (n = 10), or A769662 (20 pmol) + MGO (1.5 nmol) (n = 10). At day 3 post injection, optical coherence tomographical images (A) and H&E staining images (B) were determined. The yellow arrows in (A) indicate subretinal deposits. The black bidirectional arrows in (B) indicate the thickness of IPL and ONL. The black arrowheads in (B) indicate the broken of RPE lining. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)