Fig. 3.

LDH3 comprises LDHA and LDHB subunits with different affinities for the substrates. (A) LDH3 consists of 2 LDHA subunits and 2 LDHB subunits (B) The conversion of lactate to pyruvate is a reversible reaction. LDHA preferentially binds pyruvate and therefore catalyzes the conversion of pyruvate to lactate at a higher rate than converting lactate to pyruvate. LDHB preferentially binds lactate and catalyzes lactate to pyruvate at a greater rate than the reverse reaction.

Abbreviations: LDH: lactate dehydrogenase, NADH: nicotinamide adenine dinucleotide.