Table 1.

Association of haplotypes of the SNPs of interest with spontaneous preterm birth.

SNPs in haploblock	Haplotypes (>1%)a	Frequency in preterm delivering women	Frequency in term delivering women	p	Adjusted pb
rs13011430 | rs8179838	CT	0.67	0.74	2.66e-5	7.98e-5
	TC	0.29	0.22	2.62e-5	7.86e-5
	CC	0.03	0.03	0.91	ns
rs10775437 | rs4798497 |rs2889405 | rs4798499	GACC	0.4	0.39	0.89	ns
	GAAT	0.31	0.26	0.0015	0.0075
	AAAC	0.23	0.27	0.008	0.04
	GGCC	0.04	0.06	0.09	ns
	GAAC	0.02	0.01	0.68	ns
rs11727167 | rs114981738	AT	0.49	0.51	0.21	ns
	GT	0.35	0.33	0.35	ns
	AC	0.16	0.16	0.62	ns
rs2689089 | rs182107462	AA	0.73	0.76	0.14	ns
	CA	0.19	0.18	0.35	ns
	CC	0.08	0.07	0.28	ns
rs12669058 | rs1799041 | rs740209	AGG	0.29	0.30	0.34	ns
	CGT	0.28	0.28	0.82	ns
	AGT	0.24	0.25	0.53	ns
	AAT	0.19	0.16	0.06	ns
rs16237 | rs16238 | rs16968617	TCG	0.33	0.36	0.15	ns
	GAG	0.36	0.32	0.06	ns
	GCA	0.23	0.22	0.57	ns
	GCG	0.08	0.09	0.10	ns
rs7629800 | rs11129012	TC	0.42	0.36	0.003	0.009
	CC	0.31	0.34	0.09	ns
	CT	0.27	0.29	0.15	ns
rs75603134 | rs13180906 | rs10078386 | rs77414036	ACTT	0.48	0.41	8.44e-5	3.38e-4
	ATTT	0.30	0.35	0.0074	0.03
	ATGT	0.14	0.15	0.74	ns
	GTTC	0.07	0.09	0.07	ns
rs2327290 | rs6039882 | rs6131083 | rs6074125	CTTG	0.34	0.37	0.04	ns
	CCTA	0.22	0.26	0.0099	0.04
	ACTG	0.26	0.22	0.0094	0.04
	ACGG	0.18	0.14	0.0069	0.03

“SNPs of interest” are marked in bold.

ns means not significant.

^aHaplotypes with more than 1% frequency among the study participants were considered.

^bBonferroni-adjusted p-values have been enlisted. P-values have been adjusted for the number of tests within each block.