Table 2.
Outcome measures.
| PS group (n = 121) | CPAP group (n = 123) | Difference, PS minus CPAP (95% CI) | p value | |
|---|---|---|---|---|
| Primary outcome | ||||
| Successful extubation after first SBT n (%) | 97 (80.2) | 93 (75.6) | 4.6 (−5.8, 15) | 0.39 |
| Secondary outcomes | ||||
| First SBT pass n (%) | 111 (91.7) | 105 (85.4) | 6.3 (−1.6, 14.3) | 0.12 |
| Interval between first SBT and extubation (hours) | 2 (1.5, 4) | 2 (1, 3.5) | 0.24 (−0.13, 0.62) | 0.15 |
| Reintubation within 72 h n (%) | 14 (11.6) | 12 (9.8) | 1.8 (−5.9, 9.6) | 0.65 |
| Time to re-intubation (hours) | 24 (15.5, 36) | 18 (6.75, 58) | −6.2 (−23.2, 10.8) | 0.98 |
| Need for post extubation respiratory support n (%) | 52 (43) | 49 (40) | 3.1 (−9.2, 15.5) | 0.62 |
| Reason for post-extubation respiratory support n (%) | ||||
| Decided a priori | 23 (19) | 15 (12) | 6.8 (−2.3, 15.9) | 0.14 |
| Increased work of breathing | 23 (19) | 23 (19) | 0.3 (−9.5, 10.1) | |
| Upper airway obstruction | 3 (2.5) | 3 (2.5) | 0 (−3.8, 3.9) | |
| Cardiac dysfunction | 1 (1) | 2 (1.5) | −0.8 (−3.6, 2) | |
| Neurological/neuromuscular reasons | 2 (1.5) | 6 (5) | −3.2 (−7.7, 1.2) | |
| Successful extubation after 2nd SBT n (%) | 10 (8.3) | 17 (13.8) | −5.5 (−13.4, 2.3) | 0.17 |
| All reintubations at any point in time n (%) | 17 (14) | 18 (14.6) | −0.6 (−9.4, 8.2) | 0.90 |
| Tracheostomy n (%) | 6 (5) | 3 (2.5) | 2.5 (−2.2, 7.3) | 0.30 |
| Length of invasive ventilation (days) | 5.5 (3, 7) | 5 (3.5, 7) | 0.1 (−1.3, 1.5) | 0.96 |
| Length of PICU stay (days) | 9 (6, 15) | 8 (5.5, 13) | 1 (−1, 3) | 0.48 |
| Length of hospital stay (days) | 16 (10, 25) | 16 (10, 22) | 1.9 (−0.9, 4.7) | 0.56 |
| Unfavourable outcome n (%) | 0 (0) | 4 (3.3) | −3.3 (−6.4, −0.1) | |
| Death | 0 (0) | 1 (0.8) | ||
| Discontinued care | 0 (0) | 3 (2.5) | ||
Values are expressed in numbers (%) or median (interquartile range).