Figure 7.

A proposed regulatory network mediated by MoMns2 for fatty acid β-oxidation during infectious growth of M. oryzae.

In response to an exogenous fatty acid signal, MoMsn2 translocates from the cytosol to the nucleus, regulating expression of the fatty acid oxidation-related gene MoDCI1 by targeting its promoter. Nuclear accumulation of MoMsn2 is induced by the cAMP signaling pathway, which is activated by the fatty acid signal. MoLrp1 is involved in transduction of this signal through an endocytic process. Mutation of MoMSN2, MoLRP1, or MoDCI1 in the MoMsn2-related regulatory pathway impaired fatty acid β-oxidation, eventually resulting in accumulation of LDs and restricted infectious growth of M. oryzae.