Table 3.
Antifungal activity of selected derivatives against clinical strains in comparison with C. albicans ATCC 10231.
| Compound | *MIC90 µg mL−1 | ||||||
|---|---|---|---|---|---|---|---|
| Candida albicans ATCC 10231 | Candida albicans B3 | Candida albicans B4 | Candida albicans Gu4 | Candida albicans Gu5 | Candida albicans F2 | Candida albicans F5 | |
| 3 | 16 | 16 | 32 | 16 | 32 | 16 | 32 |
| 5 | 16 | 64 | 64 | 64 | 64 | 32 | 64 |
| 6 | 16 | 16 | 64 | 16 | 64 | 32 | 32 |
| 7 | 16 | 32 | 64 | 32 | 32 | 32 | 32 |
| 8 | 32 | 32 | 32 | 32 | 32 | 32 | 32 |
| 9 | 4 | 8 | 8 | 8 | 8 | 8 | 8 |
| 12 | 8 | 64 | 64 | 64 | 64 | > 64 | > 64 |
| 13 | 8 | 16 | 16 | 16 | 16 | 16 | 16 |
| 14 | 8 | 16 | 16 | 8 | 8 | 8 | 8 |
| 15 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
| 42 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
| 44 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| 45 | 32 | 64 | 64 | 64 | 64 | 64 | 64 |
| Fluconazole | 8 | 1 | 16 | 4 | > 64 | 8 | > 64 |
* > Means no activity at the concentration mentioned. In this assay, the MIC90 value of fluconazole was recorded as a positive control. The experiments were performed at least in three replicates.