Table 4.
Fungicidal activity of selected compounds and amphotericin B (MFC—minimal fungicidal concentration—a concentration that inhibits 99% of fungal cell growth).
| Compound | *MFC µg mL−1 | |||
|---|---|---|---|---|
| Candida albicans ATCC 10231 | Candida glabrata ATCC 90030 | Candida krusei ATCC 6258 | Saccharomyces cerevisiae ATCC 9763 | |
| 1 | 64 | > 128 | > 128 | 16 |
| 2 | > 64 | > 64 | > 64 | 64 |
| 3 | 32 | 128 | 64 | 16 |
| 4 | > 64 | > 64 | > 64 | 64 |
| 5 | 64 | > 128 | 128 | 32 |
| 6 | 32 | 128 | 64 | 8 |
| 7 | 64 | > 128 | 128 | 16 |
| 8 | 64 | > 64 | 64 | 32 |
| 9 | 8 | 8 | 8 | 4 |
| 10 | > 16 | > 16 | > 16 | > 16 |
| 11 | > 64 | > 64 | > 64 | > 64 |
| 12 | > 64 | > 64 | > 64 | > 64 |
| 13 | 32 | 32 | 8 | 16 |
| 14 | 16 | 16 | 8 | 8 |
| 15 | 64 | 64 | 32 | 16 |
| 16 | 64 | 32 | 32 | 32 |
| 25 | > 64 | > 64 | > 64 | > 64 |
| 26 | > 64 | > 64 | > 64 | > 64 |
| 34 | > 32 | > 32 | 32 | 32 |
| 42 | 8 | 8 | 4 | 4 |
| 44 | 4 | 4 | 4 | 2 |
| 45 | 32 | 32 | 32 | 32 |
| Amphotericin B | 2 | 2 | 2 | 2 |
* > Means no 99% killing activity at the concentration mentioned. Higher concentrations have not been tested due to the solubility limitations of some compounds. In this assay, the MFC value of amphotericin B was recorded as a positive control. The experiments were performed at least in three replicates.