Table 5.
The concentrations of selected compounds that totally inhibited yeast topoisomerase II-mediated relaxation activity.
| Compound | Complete inhibition [µM] | IC50 [µM] |
|---|---|---|
| 9 | > 50* | – |
| 13 | > 150 | – |
| 14 | 50 | 18.62 ± 1.81 |
| 15 | > 150 | – |
| 42 | 10 | 5.86 ± 1.07 |
| 44 | 10 | 5.36 ± 1.22 |
For selected compounds IC50—inhibitory concentrations representing a concentration that inhibits 50% of enzyme activity were determined. The experiments were performed at least in three replicates.
*Higher concentrations have not been tested due to the low solubility of the compound.