Table 4.

Results of the metabolomics-based blood test in the rats after subchronic exposure to copper oxide nanoparticles.

#	Exposure group	m/z	Quasi-molecular ion	Annotated substance	Retention time	p	Fold change	Database substance ID
1	1	623.3177	[M+Na]+	LPI(18:0)	16.94	0.0067	5.28	HMDB0240261
2		332.3324	[M+H]+	Hexadecylbenzylamine	18.01	0.0205	4.84	CID15416275
3	2	568.2653	[M+Na]+	LPS(20:4)	14.57	0.0460	2.62	LMGP03050007
4		502.2943	[M+H]+	LPE(20:4)	14.91	0.0308	2.13	HMDB0011488
5		502.2943	[M+H]+	LPE(20:4)	15.25	0.0186	4.14	HMDB0011488
6		583.3242	[M–H2O+H]+	LPI(18:0)	16.97	0.0027	12.37	HMDB0061704
7		643.2845	[M+Na]+	LPI(20:4)	14.00	0.0283	7.74	LMGP06050006
8		595.2847	[M+Na]+	LPI(16:0)	14.87	0.0283	8.70	HMDB0061695
9		295.2644	[M+H]+	Methyl linoleate	23.61	–	–	HMDB0034381
10		271.2633	[M+H]+	Methyl hexadecanoic acid	24.86	0.0040	5.07	HMDB0061859
11		429.3729	[M–H2O+H]+	alpha-Tocopherolquinone	27.08	0.0007	2.66	HMDB0034408
12		331.2859	[M+H]+	MG(16:0/0:0/0:0)	19.89	0.0009	− 2.11	HMDB0011564
13		359.3170	[M+H]+	MG(0:0/18:0/0:0)	22.31	0.0009	− 2.35	LMGL01010003
14		359.3159	[M+H]+	MG(18:0/0:0/0:0)	22.73	0.0009	− 2.31	LMGL01010003
15		239.2380	[M–H2O+H]+	Palmitic acid	19.89	0.0009	− 2.03	HMDB0000220
16		468.3094	[M+H]+	LysoPC(14:0/0:0)	14.05	0.0409	− 2.12	HMDB0010379
17		398.2301	[M+H]+	LPC(9:0)	17.83	0.0457	− 2.70	LMGP01050068
18		552.4043	[M+H]+	LysoPC(20:0/0:0)	21.78	0.0429	− 3.66	HMDB0010390
19		643.2845	[M+Na]+	LPI(20:4/0:0)	14.34	0.0283	7.74	HMDB0061690

Abbreviations: HMDB Human Metabolome Database, LM LipidMaps, CID, PubChem Compound Identification.