Table 2.

Depression questionnaire total scores (mean [SD]) per treatment group (group A JNJ-54175446, group B JNJ-54175446 post TSD, group C placebo) at different time points.

Group A (JNJ-54175446 pre and post TSD)
Time point	HDRS17	QIDS-SR			POMS
Day-1	20.0 [4.03]	13.0 [3.98]			38.88 [16.15]
Start TSD
Day 3	NP	10.7 [4.36]	29.00 [16.43]
Recovery sleep
Day 5	NP	6.7 [5.37]	15.88 [17.72]
Day 10	14.7 [4.94]	8.7 [5.24]	17.79 [17.51]
Follow Up	13.8 [5.01]	8.7 [5.07]	NP
Group B (placebo pre- TSD and JNJ-54175446 post TSD)
Day-1	18.1 [4.38]	12.2 [4.63]		34.40 [15.91]
Start TSD
Day 3	NP	10.4 [4.82]		29.08 [17.24]
Recovery sleep
Day 5	NP	5.9 [5.45]		12.92 [20.19]
Day 10	13.2 [5.16]	7.3 [5.24]		17.50 [20.64]
Follow Up	12.3 [5.63]	7.1 [5.45]		NP
Group C (Placebo)
Day-1	18.9 [4.04]	10.8 [3.52]		32.4 [15.73]
Start TSD
Day 3	NP	8.8 [3.91]		24.9 [14.87]
Recovery sleep
Day 5	NP	4.2 [4.02]		9.9 [14.81]
Day 10	13.8 [5.49]	5.9 [3.76]		10.8 [13.04]
Follow Up	12.9 [5.73]	5.1 [4.35]		NP

For the depression questionnaires, the only observed significant effects were caused by TSD.

NP not performed, TSD total sleep deprivation, HDRS17 Hamilton Depression Rating Scale, 17 items, QIDS-SR Self-rated Quick Inventory of Depressive Symptoms, POMS Profile of Mood States.