Table 4.

Anhedonia assessments total scores (mean [SD]) per treatment group at different time points.

Group A (JNJ-54175446 pre and post TSD)
Time point	SHAPS	PILT total amount won	PILT choice consistency wins	PILT total amount lost	PILT choice consistency losses
Day-1	8.6 [2.26]	17.72 [2.15]	0.79 [0.16]	14.22 [1.86]	0.61 [0.12]
Start TSD
Day 3	7.5 [3.31]	16.71 [2.54]	0.81 [0.18]	13.07 [2.17]	0.66 [0.17]
Recovery sleep
Day 5	7.4 [4.05]	17.38 [3.01]	0.83 [0.17]	12.84 [2.29]	0.68 [0.18]
Day 10	6.4 [3.96]	18.25 [2.78]	0.87 [0.14]	12.00 [1.67]	0.71 [0.17]
Group B (placebo pre- TSD and JNJ-54175446 post TSD)
Day-1	8.15 [3.50]	16.82[2.22]	0.72 [0.18]	14.54 [1.93]	0.60 [0.13]
Start TSD
Day 3	7.28 [3.58]	17.1	0.77	14.49	0.61
		[2.77]	[0.18]	[2.09]	[0.16]
Recovery sleep
Day 5	7.33 [4.28]	17.20 [2.42]	0.77 [0.20]	13.94 [2.50]	0.65 [0.17]
Day 10	5.71 [4.42]	18.33 [2.69]	0.83 [0.17]	12.36 [2.43]	0.71 [0.18]
Group C (Placebo)
Day-1	8.2 [2.68]	15.29 [2.13]	0.70 [0.17]	14.22 [1.75]	0.60 [0.08]
Start TSD
Day 3	6.9 [2.97]	16.24 [2.84]	0.79 [0.19]	14.25 [2.10]	0.65 [0.14]
Recovery sleep
Day 5	4.8 [3.17]	17.51 [3.02]	0.87 [0.17]	12.67 [2.00]	0.70 [0.17]
Day 10	4.6 [4.29]	16.92 [2.96]	0.85 [0.15]	13.02 [1.65]	0.71 [0.14]

_{TSD total sleep deprivation, SHAPS Snaith-Hamilton Pleasure Scale, PILT Probabilistic Instrumental Learning Task.}