Table 2.

Incidence Rate and Hazard Ratio for Recurrent Atherosclerotic Cardiovascular Events Associated With Lp(a) Levels.

	Recurrent ASCVD events
Events/person-years	641/10,585
Rate (95% CI) per 1,000 person-years	60.5 (55.9-65.2)
Hazard ratio (95% CI) per 1 SD higher log-transformed Lp(a)
Model 1	1.07 (0.98-1.17)
Model 2	1.03 (0.94-1.12)
Model 3	1.04 (0.95-1.15)

Note: Recurrent ASCVD events include myocardial infarction hospitalization, ischemic stroke hospitalization, peripheral artery disease hospitalization, coronary heart disease death or ischemic stroke death.

The SD of log-transformed Lp(a) was equal to 1.3 units, which represents a 3.7 times increase in Lp(a) levels in their original scale.

Model 1 includes adjustment for age, sex, Chronic Renal Insufficiency Cohort study center, race/ethnicity, education and income.

Model 2 include adjustment for variables in Model 1 and smoking status, physical activity, body mass index, diabetes, systolic blood pressure, antihypertensive medication use, estimated glomerular filtration rate, high-sensitivity C-reactive protein, and albumin-creatinine ratio.

Model 3 includes adjustment for variables in Model 2 and high-density lipoprotein cholesterol, triglycerides, fibroblast growth factor 23, homocysteine, use of aspirin and statins, and non-Lp(a) low-density lipoprotein cholesterol.

Abbreviations: ASCVD, atherosclerotic cardiovascular disease; CI, confidence interval; Lp(a), lipoprotein(a); SD, standard deviation.