Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 24;11:40. doi: 10.1038/s41413-023-00262-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — The main routes of SMA application for maintaining bone homeostasis. Two major routes of SMA applications are used for treating bone-related diseases by ameliorating bone homeostasis: a SMA-based drugs and b SMA-based biomaterials: SMA-based drugs, including drugs used for treating bone diseases and drugs for other diseases that show positive effects on bone homeostasis. SMA-based biomaterials include biomaterials on which SMAs have been physically loaded (for example, sponge-inspired sulfonated polyetheretherketone loaded with polydopamine-protected osthole nanoparticles and berberine;⁵² liposome carriers of desferrioxamine⁵³) and biomaterials with chemical engrafting of SMAs (for example, polydimethylsiloxane surface with histidine- and leucine-conjugated (3-aminopropyl)-triethoxysilane;⁵⁶ piperazine-based polyurethane-urea scaffolds⁵⁸)