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. 2023 Jul 19;15:729–738. doi: 10.2147/CMAR.S411547

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© 2023 Zhou et al.

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Inhibiting CD73 improves the anti-tumor immunity in BM immune cells isolated from patients with MM. BMMCs from patients were either untreated or treated with 10 μg/mL PSB-12379 for 12 h. (A) Flow cytometry analysis showing the residual CD138+ cells in the BMMCs culture of the groups treated with or without PSB-12379. The bar graph shows the quantitative comparison of the residual CD138+ cells in the BMMCs culture in the two groups. (B) Levels of IL-2, TNF-α, IFN-γ, IL-4, IL-6, and IL-10 in cells treated with or without PSB-12379. (C) The number of monocytes that underwent phagocytosis in myeloma cells was not significantly different between PSB-12379-treated and untreated groups; *P < 0.05.

Abbreviations: BM, bone marrow; MM, multiple myeloma; BMMCs, bone marrow mononuclear cells; IL, interleukin; TNF-α, tumor necrosis factor alpha; IFN-γ, interferon gamma.