Table 1.
Baseline and post-NaHCO3 level of urine pH, ammonium (NH4+), and citrate/creatinine in healthy volunteers and BASE participants with chronic kidney disease
| Healthy Volunteers | Baseline |
Post-NaHCO3 |
||||
|---|---|---|---|---|---|---|
| pH | NH4+ (mmol) | Citrate/Cr (mg/mg) | pH | NH4+ (mmol) | Citrate/Cr (mg/mg) | |
| Total (n=15) | 6.56 (0.67) | 32.4 (9.80) | 0.466 (0.131) | 7.23 (0.47)a | 22.0 (8.34)a | 0.549 (0.217) |
| Women (n=8) | 6.63 (0.71) | 29.4 (8.08) | 0.524 (0.129) | 7.33 (0.43)a | 17.0 (6.27)a | 0.703 (0.254) |
| Men (n=7) | 6.49 (0.67) | 35.8 (11.1) | 0.400 (0.104) | 7.17 (0.51) | 25.6 (8.10) | 0.440 (0.098) |
| P value for W vs. Mb | 0.70 | 0.23 | 0.06 | 0.58 | 0.07 | 0.08 |
| P value for difference in mean change for W vs. Mc | — | — | — | 0.99 | 0.84 | 0.19 |
| BASE Participants | Baseline |
Post-NaHCO3 |
||||
|---|---|---|---|---|---|---|
| pH | NH4+ (mmol) | Citrate/Cr (mg/mg) | pH | NH4+ (mmol) | Citrate/Cr (mg/mg) | |
| Total (n=123) | ||||||
| LD-NaHCO3 (n=47) | 5.86 (0.46) | 19.8 (10.8) | 0.195 (0.166) | 6.61 (0.55)a | 13.5 (8.1)a | 0.284 (0.182)a |
| HD-NaHCO3 (n=76) | 5.75 (0.46) | 22.7 (12.9) | 0.151 (0.137) | 6.73 (0.56)a | 13.1 (9.4)a | 0.262 (0.172)a |
| Women | ||||||
| LD-NaHCO3 (n=16) | 5.96 (0.50) | 17.7 (10.4) | 0.243 (0.195) | 6.65 (0.61)a | 10.7 (3.7)a | 0.386 (0.257) |
| HD-NaHCO3 (n=21) | 5.80 (0.49) | 19.1 (10.8) | 0.177 (0.157) | 6.79 (0.61)a | 11.1 (8.1)a | 0.302 (0.132)a |
| Men | ||||||
| LD-NaHCO3 (n=31) | 5.79 (0.42) | 20.9 (11.0) | 0.170 (0.147) | 6.58 (0.53)a | 14.9 (9.3)a | 0.235 (0.106)a |
| HD-NaHCO3 (n=55) | 5.73 (0.45) | 24.1 (13.5) | 0.141 (0.128) | 6.70 (0.55)a | 13.9 (9.8)a | 0.248 (0.183)a |
| P value for W vs. Mb | ||||||
| LD-NaHCO3 | 0.20 | 0.33 | 0.20 | 0.66 | 0.03 | 0.04 |
| HD-NaHCO3 | 0.54 | 0.10 | 0.36 | 0.54 | 0.22 | 0.17 |
| P value for difference change for W vs. Mc | ||||||
| LD-NaHCO3 | 0.70 | 0.33 | 0.20 | |||
| HD-NaHCO3 | — | — | — | 0.89 | 0.36 | 0.83 |
Note: Values reported as mean (SD); post-NaHCO3 values are the average of values of urine sample at the week 12 and week 28 visit of participants with chronic kidney disease from the BASE Pilot Trial.
Abbreviations: Cr, creatinine; HD, high dose; LD, low dose; NH4+, ammonium; NaHCO3, sodium bicarbonate; pH, potential hydrogen; W, women; M, men.
P value <0.05 for comparison between baseline parameters and parameters after administration of NaHCO3.
P value is for comparisons between women and men at the same visit.
P value is for comparisons of the mean change from baseline parameters in women and men.