Table 2.
Pregnancy, Delivery, and Neonatal Outcomes of 47 Live Births According to Condition (a) before cTMA, (b) with cTMA, and (c) after cTMA
| Before cTMA (a) | With cTMA (b) | Following cTMA (c) | P | |
|---|---|---|---|---|
| Gestational age, wk (95% CI) | 39.0 (37.3 to 40.7) | 36.5 (34.6 to 38.4) | 37.2 (35.4 to 38.9) | 0.1 |
| Comparison with (a), wk (95% Dunnett CI) | - | −2.5 (−5.2 to 0.2) | −1.8 (−4.3 to 0.7) | |
| Gestational age, weeks (95% Dunnett CI)a | 39.2 (37.9 to 40.6) | 36.5 (34.7 to 38.3) | 37.9 (36.4 to 39.3) | 0.045 |
| Comparison with (a), wk (95% CI) | - | −2.8 (−5.3 to −0.3) | −1.4 (−3.5 to 0.7) | |
| Birth weight, centile (95% CI) | 42.4 (26.6 to 58.3) | 39.7 (18.6 to 60.9) | 38.5 (21.8 to 55.3) | 0.93 |
| Comparison with (a), centile (95% Dunnett CI) | - | −2.7 (−32.9 to 27.6) | −3.9 (−29.6 to 21.8) | |
| Birth weight, centile (95% CI)b | 43.4 (28.4 to 58.3) | 28.0 (6.0 to 50.1) | 42.0 (26.0 to 58.0) | 0.47 |
| Comparison with (a), centile (95% Dunnett CI) | - | −15.3 (−46.4 to 15.7) | −1.4 (−25.7 to 22.9) | |
| Length at birth, centile (95% CI) | 33.6 (19.9 to 47.3) | 31.2 (12.9 to 49.6) | 51.2 (37.5 to 65.0) | 0.1 |
| Comparison with (a), centile (95% Dunnett CI) | - | −2.4 (−29.0 to 24.2) | 17.6 (−4.4 to 39.6) | |
| Head circumference, centile (95% CI) | 35.2 (18.0 to 52.4) | 46.3 (24.8 to 67.8) | 37.4 (20.8 to 54.0) | 0.68 |
| Comparison with (a), centile (95% Dunnett CI) | - | 11.1 (−20.5 to 42.7) | 2.2 (−24.6 to 29.0) | |
| Head circumference, centile (95% CI)b | 36.1 (20.3 to 51.8) | 35.0 (13.0 to 56.9) | 40.6 (25.4 to 55.8) | 0.86 |
| Comparison with (a), centile (95% Dunnett CI) | - | −1.1 (−32.7 to 30.5) | 4.5 (−20.1 to 29.2) | |
| Weight gain velocity, g/d (95% CI) | 199 (125 to 274) | 204 (120 to 287) | 252 (182 to 321) | 0.39 |
| Comparison with (a), g/d (95% Dunnett CI) | - | 4 (−121 to 130) | 52 (−55 to 159) | |
| Weight gain velocity, g/d (95% CI)c | 196 (155 to 237) | 228 (171 to 284) | 219 (179 to 260) | 0.55 |
| Comparison with (a), (95% Dunnett CI) | - | 32 (−50 to 114) | 23 (−43 to 89) |
Abbreviations and definitions: cTMA, complement mediated thrombotic microangiopathy; CI, confidence interval (corrected for two pairwise comparisons within each outcome model using Dunnett’s method).
a
Excluding pregnancy 4-1 (extreme preterm) and pregnancy 16-1 (large for gestational age).
b
Excluding pregnancy 16-1 (large for gestational age).
c
Excluding pregnancy 4-1 (extreme preterm) and 25-1 (rapid growth).